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A novel mechanical approach to sorting Caenorhabditis elegans and other nematode species for age-synchronized, large-scale assays.The Problem: The most common method of C. elegans transfer is to use a fine, sterilized “pick” made of hair or wire to move animals individually or in small groups. Many procedures, such as RNA extraction or fluorescent...

Published: 9/19/2017 | Inventor(s): Skyler Hunter, Elena Vayndorf

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Category(s): Biotechnology

Using Alpha 4 Beta 2 Selective Positive Allosteric Modulators for the Treatment of OCD and OCD Spectrum Disorders

The Market: Pharmaceutical companiesDescription:This invention addresses the problem of developing a drug therapy for the treatment of obsessivecompulsive (OCD) spectrum disorders. Current approaches to the treatment of OCD typicallyinvolve the use of antidepressants classically categorized as selective serotonin reuptakeinhibitors. These medications...

Published: 9/19/2017 | Inventor(s): Abel Bult-Ito, Swarup Mitra

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Category(s): Biotechnology

MyoCanine

Aging is generally associated with a progressive gain in fat mass and loss of muscle mass. Although weight loss by caloric restriction might be anticipated to be of benefit, traditional caloric restriction-induced weight loss typically promotes an acceleration of muscle atrophy, and further reductions in physical function despite weight loss. Consequently,...

Published: 8/15/2016 | Inventor(s): Robert Coker

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Category(s): Biotechnology

Novel Synthesis of Sphingosine Analogues as Potential Drug Candidates

UAF researchers have developed an invention relating to the synthesis of stereochemical framework that is fundemental to the structure of sphingosines. The method is unique and is applicable in the production of a wide variety of sphingosine analogues, molecules that have potential in the treatment of cancer. Sphingosines can inhibit the rapid increase...

Published: 8/15/2016 | Inventor(s): Tom Green, Zhipeng Dai

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Category(s): Biotechnology

Cryotube Vial Design

Cryogenic vials are designed for long-term storage of biological material at ultra-low temperatures andare used by museums, research labs, and other facilities to archive samples in perpetuity. Currently, cryovials are offeredin a limited range of volumes and dimensions. As more samples are cryogenically preserved, more space is needed toaccommodate...

Published: 8/15/2016 | Inventor(s): Link Olson, Aren Gunderson, Kyndall Hildebrandt

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Category(s): Biotechnology

Pathogen Detection Method

Dr. Chen developed a technology that can be used to greatly enrich pathogenic sequences in human clinical samples. This method does not require prior knowledge of the pathogen or assumption of the infection, and therefore, provides a fast and sequence-independent approach to identify human pathogens. In combination with Illumina next generation sequencing...

Published: 4/7/2017 | Inventor(s): Jiguo (jack) Chen, Fang Ge

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Category(s): Biotechnology

Hunt for Brain Regions Involved in Season Dependent A1AR Agonist-Induced Torpor

Dr. Kelly Drew’s laboratory at the University of Alaska Fairbanks has developed a novel pharmacological adjunct for inducing therapeutic hypothermia that circumvents the problematic side effectof shivering to help medical professionals mitigate neurological damage in conscious patients following cerebral ischemia. The novel method calls for the...

Published: 8/15/2016 | Inventor(s): Kelly Drew, Tulasi Jinka, Lori Bogren, Isaac Bailey, Jasmine Olson, Zachary Carlson

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Category(s): Biotechnology